Durable BRAIN

Why It Works

Brain fog, trouble focusing and memory lapses may seem like a normal part of getting older. But here’s the truth: Even in healthy adults, the earliest signs of cognitive decline can start as early as your 40s or 50s. And without the right support, these changes often progress gradually over time. Factors like stress, nutrient deficiencies, environmental toxins, pollution, oxidative damage and age-related declines in key neurotransmitters can all take a toll on mental clarity, focus and memory.

Many of Dr. Passero’s patients come to him feeling frustrated by the lack of effective solutions conventional doctors have to offer for cognitive concerns. They’re often encouraged to discover that Dr. Passero has had significant success using natural nootropics—herbs and nutrients clinically shown to boost focus, memory, mood and motivation while supporting long-term brain health. The word nootropic comes from the Greek for “to shape or bend the mind.

Synthetic nootropics can carry unwanted side effects, which is why many people seek natural alternatives. Unfortunately, many products marketed as “nootropics” rely heavily on caffeine or other stimulants to create a fast, noticeable jolt of alertness. While this may feel effective at first, it often overstimulates the nervous system and pushes neurotransmitters beyond their natural balance—and does nothing to promote the long-term health of your brain.

Natural nootropics, by contrast, work with your brain’s biochemistry to support clear, steady thinking and long-term cognitive resilience—without jitters, racing thoughts or the spike-and-crash effect commonly associated with stimulants.

Drawing on more than two decades of clinical experience, Dr. Kevin Passero formulated Durable BRAIN based on his comprehensive 5-Point Brain Health Protocol to include a powerful, synergistic blend of the most rigorously studied natural nootropics in the world—ingredients he has used successfully for years to address the root causes of cognitive slowdown.

Dr. Passero’s 5-Point Brain Health Protocol

1. Enhance focus and learning with targeted support from Nutricog® botanical blend
2. Improve memory formation and recall with targeted support from Synapsa® bacopa
3. Increase cognitive resilience and neuroplasticity—the brain’s ability to adapt, grow and form new connections—with Nutricog®, Synapsa® and lion’s mane mushroom
4. Fight oxidative stress and boost cerebral blood flow—and the delivery of oxygen and nutrients to the brain—with Gingkoselect® ginkgo biloba
5. Protect, repair and regenerate brain cells and nerves with lion’s mane and methylated vitamin B12

At the core of this all-in-one, multi-action formula is Nutricog®, a patented botanical blend shown in human trials to dramatically boost focus and learning speed, with noticeable results beginning in as little as 15 days. Nutricog® has also been shown to more than double levels of serum BDNF (brain-derived neurotrophic factor), a key protein associated with improved learning, mood and brain adaptability.

To reinforce these gains, Synapsa® bacopa improves memory accuracy and reduces mental fatigue over time, while Ginkgoselect® promotes healthy circulation, mood, sleep and day-to-day cognitive function, particularly in older adults.

Completing the formula, organic lion’s mane mushroom stimulates NGF (nerve growth factor) to help nourish and protect brain cells, while methylated vitamin B12 delivers the bioactive form required for healthy nerve signaling, brain metabolism and sustained cognitive energy.

Whether you’re feeling mentally foggy, easily distracted, or simply not as sharp as you once were, Durable BRAIN is designed to restore peak cognitive performance by nourishing the core systems that power your mind—naturally and sustainably.

Nutricog®: Advanced Botanical Complex for Focus, Learning & Neuroplasticity (300 mg)
Nutricog® is a groundbreaking botanical blend of the Ayurvedic herbs Boswellia serrata (shallaki) and Terminalia chebula (haritaki), standardized to deliver high levels of gallic acid, ellagic acid and amyrins—powerful compounds with proven cognitive effects.

In a double-blind, placebo-controlled human clinical trial, Nutricog® delivered remarkable results with improvements beginning in just 15 days: a 11.5x increase in focus, 2.7x faster learning speed, and significant improvements in both immediate and delayed memory recall.

What truly sets Nutricog® apart is its impact on (brain-derived neurotrophic factor), a key protein involved in neuroplasticity—the brain’s ability to form, strengthen and rewire neural connections. Participants taking Nutricog® more than doubled their serum BDNF levels, suggesting powerful long-term benefits for learning, memory formation and emotional resilience.

With effects beginning in as little as 15 days, Nutricog® provides fast, measurable improvements in focus and mental clarity—without relying on stimulants or harsh synthetics.

Sustainably sourced and standardized for potency, it’s the ideal foundation for anyone seeking to elevate their cognitive performance safely and effectively.

Synapsa® Bacopa: Clinically Validated Memory Support (320 mg)
One of the most rigorously studied natural nootropics, bacopa (Bacopa monnieri) is known to contain unique and powerful antioxidants called bacosides that are among the few substances that can easily cross the blood-brain barrier to protect neurons from oxidative stress.

Bacosides also have the remarkable ability to increase BDNF levels, promoting neuroplasticity, better memory, faster learning and better overall cognitive health.

Durable BRAIN features a full clinical-strength 320 mg dose of Synapsa®—a patented, standardized, whole-plant extract of bacopa. Unlike generic bacopa, Synapsa® is supported by over 30 years of research and seven double-blind, placebo-controlled human clinical trials involving nearly 1,000 participants across multiple age groups.

In clinical trials, Synapsa® has been shown to significantly improve multiple aspects of cognitive performance, including:

• Enhanced memory retention and recall, particularly verbal memory
• Improved learning rate and faster information processing
• Greater mental performance and reduced forgetfulness
• Improved focus and cognitive speed, especially during tasks that require sustained attention

Unlike short-term stimulants that offer temporary alertness, Synapsa® delivers long-term support for brain resilience and performance under pressure. It has been clinically studied in both younger adults seeking mental sharpness and older adults concerned with cognitive aging.

In one notable clinical trial, people who took 300 mg of Synapsa® daily for 90 days saw a 5.5x greater improvement in their working memory test scores—reflecting quicker thinking and sharper information recall.

Other clinical trials have shown measurable improvements in memory, learning and reaction time after just 6 weeks of daily use, with optimal benefits seen at the 90-day mark—using the powerful 320 mg daily dose of Synapsa® found in Durable BRAIN.

Ginkgoselect® Ginkgo Biloba: Enhances Blood Flow to the Brain (150 mg)
Ginkgoselect® is a pharmaceutical-grade extract of Ginkgo biloba, standardized to match the exact composition used in decades of published scientific research. Each dose delivers ≥24% ginkgo flavone glycosides and ≥6% terpene lactones—the key bioactive compounds responsible for ginkgo’s well-documented benefits for circulation, mood and cognitive function.

Because ginkgo is one of the most adulterated herbal extracts on the market, we chose a pharmaceutical-grade version to ensure exceptional purity, consistency and safety. Ginkgoselect® is carefully purified to contain ≤5 ppm of ginkgolic acids, compounds associated with irritation and long-term safety concerns in lower-quality ginkgo extracts.

By enhancing cerebral microcirculation, Ginkgoselect® helps ensure that oxygen and vital nutrients are delivered efficiently to brain tissue—supporting sharper thinking, better memory performance and long-term cognitive health.

Clinical studies on Ginkgo LI 1370 (the class to which Ginkgoselect® belongs) have shown that a daily dose of 120-150 mg can preserve daily functioning and alertness in older adults, support mood and emotional balance, and improve sleep quality and morning readiness. In a 10-month follow-up study, participants who continued supplementation saw greater gains in mood, cognitive resilience and their ability to perform everyday activities—while those who stopped experienced regression toward baseline.

Organic Lion’s Mane Mushroom: Targeted Support for Nerve Growth & Repair (500 mg)
Lion’s mane (Hericium erinaceus) is a remarkable nootropic mushroom with the rare ability to stimulate the synthesis of nerve growth factor (NGF)—a key protein that supports the growth, repair and survival of neurons. NGF is essential for maintaining healthy brain function and promoting neuroplasticity, the brain’s ability to rewire and adapt to new information.

Durable BRAIN features a full-spectrum, certified organic extract of lion’s mane, grown on whole organic oats and composed of both fruiting body and mycelial biomass. This full-spectrum approach ensures a wider array of naturally occurring bioactive compounds, including hericenones and erinacines—compounds believed to drive lion’s mane’s NGF-stimulating activity.

Dr. Passero specifically chose organic lion’s mane grown in the USA to ensure exceptional purity and quality, as conventionally grown mushrooms may be exposed to environmental contaminants.

Lion’s mane works synergistically with Nutricog® and Synapsa® to promote long-term brain adaptability and repair. It supports the regeneration of damaged neurons, enhances communication between brain cells, and helps restore cognitive function under stress or age-related decline.

Methylated Vitamin B12: An Essential Nutrient for Nerve Function & Mental Energy (250 mcg)
Vitamin B12 is a critical cofactor in numerous biochemical processes essential to brain and nervous system function. It plays a key role in the synthesis of neurotransmitters, the formation of the protective myelin sheath around nerves, and the regulation of homocysteine levels, which when elevated, have been associated with cognitive decline and brain atrophy.

Durable BRAIN features methylcobalamin, the methylated form of B12, which has been shown to be the most bioactive and neurologically supportive form. Unlike the synthetic form (cyanocobalamin) found in many supplements, methylcobalamin is bioidentical to the naturally occurring B12 used in human physiology and is readily absorbed and utilized by the brain, even in individuals with impaired methylation pathways.

B12 deficiency is surprisingly common, especially in older adults, vegetarians and those with digestive issues. Low B12 can cause fatigue, memory loss, difficulty concentrating, irritability, and even mood disorders. Research shows that adequate B12 levels may:

• Improve memory recall and mental sharpness
• Support a healthy mood and reduce cognitive fatigue
• Help prevent age-related memory decline
• Promote neurological repair and long-term brain protection

The 250 mcg dose in Durable BRAIN helps ensure that your brain has the support it needs to stay energized, focused and resilient—especially as you age.

Why We Use Amber Glass Bottles vs. Clear Glass or Plastic:

• Sustainability: Glass is infinitely recyclable and reusable.
• UV Protection: Amber glass protects the ingredients from light damage.
• 100% Non-Toxic: No risk of chemicals found in plastics leaching into the pills.