Durable LONGEVITY

Why It Works

We all want to age well—and live well for as long as possible. And while there are many factors that contribute to healthy aging and longevity, scientists are beginning to understand some key cellular mechanisms that influence how we age. Nearly all of the common complaints we associate with aging, from joint pain, fatigue and brain fog to declining vision and wrinkles, are a result of our cells getting worn out and damaged over time.

The great news is cutting-edge research is revealing that we have some control over our cellular aging process—and that key antioxidants and inflammation fighters can play a major role in making our cells biologically younger.

That’s why Dr. Passero formulated Durable LONGEVITY, drawing on over 20 years of clinical experience and research, with two natural, plant-based compounds shown to be among the most effective on earth for combatting cellular aging—Zanthin® astaxanthin and Pomella® pomegranate extract. These multifunctional antioxidants target the fundamental causes of aging, rejuvenating cells and helping you look and feel younger, longer.

Zanthin® Astaxanthin (12 mg): A Triple-Strength Dose for Maximum Effectiveness

Zanthin® astaxanthin is the finest, highest quality form of astaxanthin on the planet. Naturally sourced exclusively from microalgae grown in a remote, pristine, controlled environment in Chile, Zanthin® is extracted in the USA without solvents or harmful chemicals using a Deep Extract® high pressure supercritical CO2 extraction process and Peroxidation Blocker Stabilization technology (O2B®) to ensure the utmost purity and potency.

While many supplements only have 4 mg of generic (and often synthetic) astaxanthin that provides far less health benefits, Durable LOVGEVITY features a triple-strength 12 mg dose of Zanthin® based on the dozens of studies that demonstrate astaxanthin’s benefits are the most profound at this level.

Astaxanthin is widely considered nature’s most powerful antioxidant. It was shown in recent groundbreaking NIH-funded research to extend lifespan in mammals by up to 12%, which equates to 9+ years. The results of this important study, conducted as part of the Interventions Testing Program (ITP) supported by NIH’s National Institute on Aging, singled out astaxanthin as one of only a few compounds on earth scientifically proven to significantly extend lifespan.

The ITP examines the impact of anti-aging compounds on lifespan and is widely recognized as the gold standard in longevity research. Since longevity is difficult to study in humans because of our long lifespans, the researchers start by testing the anti-aging compound on fruit flies and other very short-lived invertebrates, and if the data is promising, they move to study it in mice or other mammals. Astaxanthin is the first compound in the ITP’s 20-year history shown to yield more than a 10% increase in mammalian lifespan that is also considered exceptionally safe for daily use.

Additional studies have shown that astaxanthin “switches on” both Nfr2 and FOX03, two gene activators closely linked to longevity and protection against aging in humans.

The secret to astaxanthin's effectiveness may lie in its unique molecular structure, which is identical to that of the human cell membrane. This allows it to span the entire cell membrane, simultaneously providing protection in both the inner and outer regions of the cell. No other antioxidant has this capability, allowing astaxanthin go where other antioxidants can’t to mount a powerful defense against oxidative stress, DNA damage and inflammation—keys to maintaining healthy, resilient, biologically younger cells.

Numerous clinical studies have shown that these cellular benefits translate into powerful anti-aging support and protection for your heart, brain, eyes, skin and more. In addition, Zanthin® astaxanthin can help you stay active, thanks to its proven ability to improve joint comfort, muscle endurance, exercise performance and post-workout recovery.

At the 12 mg dose, which is three times the amount found in typical supplements, Zanthin® astaxanthin has been scientifically proven to:

1. Combat Oxidative Stress from Reactive Oxygen Species: Oxidative stress leads to a cascade of cellular damage, including damage to DNA and mitochondria, that leads to body-wide inflammation, contributing to various age-related conditions. Clinical research has demonstrated that Zanthin® astaxanthin possesses up to 6,000 times the free radical neutralizing power of other well-known antioxidants.

2. Neutralize DNA Damage: Caused by oxidative stress, DNA damage can accelerate aging. A 2010 study showed that Zanthin® astaxanthin prevented the progression of cellular DNA damage within four weeks while reducing inflammation, with effects confirmed again at eight weeks.

3. Reduce Body-Wide Inflammation: Age-related inflammation driven by oxidative stress, often referred to as inflamm-aging, has been linked to numerous health issues and is considered a major driver of the aging process itself. A 2016 study indicated that Zanthin® astaxanthin downregulated pro-inflammatory cytokines and upregulated anti-inflammatory cytokines, resulting in a significantly reduced inflammatory response. Astaxanthin also acts as an immunomodulator, ensuring a proper immune response to manage inflammation.

Pomanox® Pomegranate Extract (300 mg): Proven to Boost Levels of Cell-Energizing Urolithin A

While astaxanthin provides extraordinarily powerful support for cellular rejuvenation and healthy, resilient aging, there’s another antioxidant-packed ingredient emerging from the research that provides a unique and exciting anti-aging benefit Dr. Passero wanted to harness.

Derived from pomegranate, a fruit known for its longevity-enhancing benefits since ancient times, Pomella® is a proprietary, clinically studied whole fruit pomegranate extract standardized to provide 30% punicalagins, a unique type of antioxidant polyphenol classified as an ellagitannin and known to offer powerful health benefits. This is a much higher level than what pomegranate juice and other extracts provide, helping to overcome the absorption issues associated with ellagitannins to ensure maximum efficacy.

Also, unlike pomegranate juice and many pomegranate extracts, Pomella® captures the full antioxidant profile found naturally in whole pomegranate fruits—including the peel, pith and seeds. And it’s the only pomegranate extract clinically proven to boost levels of urolithin A—a rare cell-energizing compound produced in the gut through the metabolism of pomegranate’s punicalagins. In this way, Pomella® also acts as a prebiotic, enhancing gut microbiome health and gut barrier function.

Urolithin A is a revolutionary anti-aging compound that triggers mitophagy, a crucial process that cleans up dysfunctional mitochondria and helps them repair and recycle themselves, optimizing mitochondrial function. Healthy mitochondria are essential for cellular energy production, and their optimal function is key to resilience, energy, strength and longevity.

Clinical research has shown that urolithin A boosts energy and significantly improves muscle function in middle-aged and older adults. It has also been shown to extend lifespan while enhancing cognitive health. Researchers believe that urolithin A, along with the other beneficial punicalagins found in pomegranate, may be able to activate critical antioxidant enzymes in the body, and recent research on Pomella® confirms this theory.

A randomized, double-blind, placebo-controlled, parallel trial found that a 300 mg daily dose of Pomella® yielded the following improvements in antioxidant status:

• Total antioxidant activity increased by 379%
• Superoxide dismutase (SOD), an enzyme that protects cells from oxidative stress, increased by 149%
• Glutathione peroxidase, the enzyme responsible for making glutathione, the body's master antioxidant) increased by 230%
• Glutathione reductase, the enzyme that activates glutathione, increased by 163%

Pomella®, at a dose of 300 mg per day, is also clinically proven to significantly reduce the appearance of fine lines and wrinkles within just 4 weeks. Researchers believe Pomella®’s remarkable anti-aging skin health benefits may be tied to its beneficial impact on the gut and skin microbiomes and ability to prevent the breakdown of collagen fibers in the skin.

Other research focused on pomegranate’s well-known heart health benefits demonstrated that Pomella® decreased total and LDL cholesterol levels while improving HDL (good) cholesterol functionality and other parameters of cardiovascular health.

Pomella® is fully traceable to orchards in India, where pomegranates are sustainably grown to maximize quality and polyphenol content. It is Certified Glyphosate Residue-Free and Non-GMO Project Verified.

Dr. Passero says this is one supplement he takes each and every day to support cellular rejuvenation, resilient aging, and overall health and longevity. If you’re looking to optimize your cellular health and effectively slow down the aging process, you’ll find the antioxidant firepower you need in Durable LONGEVITY’s unique and potent combination of Zanthin® astaxanthin and Pomella® pomegranate extract.

Why We Use Amber Glass Bottles vs. Clear Glass or Plastic:

• Sustainability: Glass is infinitely recyclable and reusable.
• UV Protection: Amber glass protects the ingredients from light damage.
• 100% Non-Toxic: No risk of chemicals found in plastics leaching into the pills.