Durable JOINTS

Why It Works

Stiff, aching joints can slow you down and keep you from doing the things you love. That’s why supporting your joint health as you age is essential for staying active and living life on your terms. Triple-action Durable JOINTS delivers clinically effective doses of three proven ingredients—UC-II® undenatured type II collagen, OptiMSM® and Albion® boron—to help restore comfort and mobility in your knees, wrists, back, neck and other joints.

In over 20 years of helping patients address joint pain and mobility issues naturally, Dr. Passero has found these three ingredients to deliver the most effective joint health support. What makes them so powerful is that, when taken together, they work synergistically to help repair and rebuild cartilage and connective tissue, deactivate inflammation, and restore comfort and mobility to joints throughout your body.

UC-II®: The Only Collagen Proven to Rebuild Joints (40 mg)
Wear and tear on your joints can trigger your immune system to respond with inflammation. Research shows that immune-driven inflammation is a major cause of the decline in joint health and function many of us experience as we age.

UC-II® undenatured type II collagen works through a unique mechanism that harnesses the power of your immune system. It triggers cells within the joints to increase collagen production, repair damage, and reduce inflammation and pain.

Backed by nearly 20 years of scientific research, UC-II®’s unique benefits have been proven in numerous industry-leading studies, including 11 human clinical trials on both younger and older adults.

Roughly 90% of the collagen found in cartilage is type II—the exact type you want to be taking for joint health. Types I and III, which are commonly found in collagen supplements targeting skin, do virtually nothing to support your joints. UC-II® is the most clinically studied form of type II collagen and the only collagen on the market that works via the immune system to stimulate cartilage production and reduce inflammation.

UC-II® is undenatured, meaning it’s produced using a patented low-temperature process that preserves the bioactive three-dimensional structure of type II collagen. This intact structure allows UC-II® to remain stable through stomach acid and digestive enzymes. This process preserves active binding regions called epitopes, which interact with immune cells in your gut and trigger an immune response that stimulates cartilage-forming cells known as chondrocytes. Other type II collagen products are made with heat and harsh processing that destroys its natural structure.

In contrast, many other type II collagen products are manufactured using heat and harsh processing methods that denature the collagen, destroying its natural structure and reducing its biological activity.

Unlike many collagen products, which are sourced overseas, UC-II® is made exclusively from USA-grown, non-GMO chicken sternum cartilage and is certified by third-party testing to be glyphosate-free. This is important because much of the type II collagen on the market is made from GMO grain-fed chickens and is often contaminated with glyphosate, a common herbicide linked to negative health effects.

UC-II® Is Over Twice as Effective as Glucosamine-Chondroitin at Reducing Pain and Improving Mobility
Research shows a 40 mg daily dose of UC-II® is more than twice as effective at reducing joint pain compared to popular glucosamine-chondroitin supplements, which require multiple large pills per day. It also outperforms hydrolyzed collagen, which is denatured and often requires a daily dose of up to 20,000 mg. With the UC-II® in Durable JOINTS, you get the most effective support for cartilage regeneration, mobility and pain relief in just 40 mg (2 small capsules per day)—no bulky pills or powders required.

In one notable study, a 40 mg daily dose of UC-II® was shown to increase joint range of motion 15x in just 8 weeks! This clinical trial, conducted on healthy adults aged 20-55, found that UC-II® improved knee flexion by 3 degrees in 8 weeks—an impressive result considering that by one CDC estimate, the average adult loses 1 degree of knee flexion and extension per decade. That means, according to these study findings, UC-II® could help your knees move and feel like they did 10, 20 or even 30 years ago!

In another study conducted on healthy adults in the same age group, the same 40 mg daily dose of UC-II® significantly reduced knee pain during activities like twisting and walking while decreasing joint discomfort post-exercise. As a result, participants in the UC-II® group ended up walking an extra 747 steps daily on average! Other research has shown that UC-II® improves joint mobility and comfort in active adults after strenuous exercise.

OptiMSM®: A Bioavailable Form of Sulfur That Builds Healthy Joints (1,500 mg)
Methylsulfonylmethane, commonly known as MSM, is a naturally occurring sulfur compound and antioxidant found in plants, animals and humans. MSM has a unique ability to combat the oxidative stress that drives joint degradation and pain by balancing the body’s antioxidant systems to help protect collagen fibers and cartilage. Through its unique antioxidant mechanism, MSM has been shown to improve recovery in athletes after intense training.

MSM also reduces inflammation—the main driver behind joint pain. Ongoing inflammation can damage cartilage, increase stiffness and limit mobility. Working in perfect synergy with the collagen-boosting effects of UC-II®, MSM protects newly formed and existing collagen from the degrading effects of immune-driven inflammatory compounds like interluken-1 commonly found in aging and painful joints.

MSM also enhances the collagen-building effects of UC-II by providing an abundant source of sulfur, which is essential for the production of collagen and keratin—two key proteins that contribute to joint structure, skin elasticity and tissue strength. By supporting collagen synthesis, MSM may help preserve cartilage and improve joint flexibility over time.

Numerous clinical trials have demonstrated MSM’s benefits for joint health. Participants reported decreased joint pain, improved mobility and better overall function after just a few weeks of supplementation.

OptiMSM® is ultra-pure, non-GMO and the most clinically studied form of MSM. Notably, a recent randomized, double-blind, placebo-controlled trial showed that a 1,000 mg daily dose of OptiMSM® enhanced joint comfort and post-exercise muscle recovery by improving the body’s antioxidant and inflammatory responses following exercise.

OptiMSM® is produced in the USA using a proprietary multi-stage distillation process—unlike other MSM made via crystallization, which can trap heavy metals and impurities. This ensures maximum purity, potency and safety. Each batch of OptiMSM® is rigorously third-party tested to meet the highest quality standards and it is widely recognized as the purest commercially produced MSM in the world.

Albion® Boron (5 mg)
Boron is a trace mineral that often flies under the radar, but it plays a surprisingly critical role in supporting joint and bone health. Naturally found in foods like nuts, leafy greens, avocados and prunes, boron supports joint function through its effects on inflammation, bone metabolism and hormone balance.

Boron helps reduce levels of inflammatory markers in the body—such as C-reactive protein (CRP)—which in turn helps ease joint discomfort and improve mobility. Research suggests people living in boron-rich regions experience fewer joint issues than those in boron-deficient areas.

Boron also supports bone health by helping the body use important nutrients like calcium, magnesium, phosphorus and vitamin D. It is also essential for maintaining bone density and joint strength—especially with age.

Clinical studies on boron supplementation show promising results, with several trials reporting reduced joint pain and improved mobility within weeks of consistent use. The research is clear: Boron is an invaluable addition to a comprehensive joint support regimen.

Made in the USA by Albion®, the global leader in high-absorption minerals, this chelated form of boron glycinate offers exceptional bioavailability and purity. Chelation enhances absorption, ensuring your body gets the full benefits of this often-overlooked mineral.

Why We Use Amber Glass Bottles vs. Clear Glass or Plastic:

• Sustainability: Glass is infinitely recyclable and reusable.
• UV Protection: Amber glass protects the ingredients from light damage.
• 100% Non-Toxic: No risk of chemicals found in plastics leaching into the pills.